RESEARCH & DEVELOPMENT
PUBLICATIONS
PUBLICATIONS
3rd Generation of Tissue Repair
Kreuz PC, Müller S, Freymann U, Erggelet C, Niemeyer P, Kaps C, Hirschmüller A.
"Repair of focal cartilage defects with scaffold-assisted autologous chondrocyte grafts: clinical and biomechanical results 48 months after transplantation. "
Am J Sports Med. 2011 Aug;39(8):1697-705.
Patrascu JM, Freymann U, Kaps C, Poenaru DV.
"Repair of a post-traumatic cartilage defect with a cell-free polymer-based cartilage implant: A follow-up at two years by mri and histological review. "
J Bone Joint Surg Br. 2010:92:1160-1163.
Endres M, Abbushi A, Thomale UW, Cabraja M, Kroppenstedt SN, Morawietz L, Casalis PA, Zenclussen ML, Lemke AJ, Horn P, Kaps C, Woiciechowsky C.
"Intervertebral disc regeneration after implantation of a cell-free bioresorbable implant in a rabbit disc degeneration model."
Biomaterials. 2010 Aug;31(22):5836-41.
Zantop T, Petersen, W.
"Arthroscopic Implantation of a matrix to cover large chondral defect during microfracture: case report with video illustration. "
Arthroscopy. 2009 Nov;25:1354-1360.
Erggelet C, Endres M, Neumann K, Morawietz L, Ringe J, Haberstroh K, Sittinger M, Kaps C.
"Formation of Cartilage Repair Tissue in Articular Cartilage Defects Pretreated with Microfracture and Covered with Cell-Free Polymer-Based Implants."
J Orthop Res. 2009 Oct;27(10):1353-60.
Kreuz PC, Muller S, Ossendorf C, Kaps C, Erggelet C.
"Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four year clinical results."
Arthritis Res Ther. 2009 Mar 5;11(2):R33
Ossendorf C, Kaps C, Kreuz PC, Burmester GR, Sittinger M, Erggelet C.
"Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results." Arthritis Res Ther. 2007;9(2):R41.
Schmelzeisen R, Schimming R, Sittinger M.
"Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary report." Journal of Craniomaxillofacial Surgery. 2003 Feb;31(1):34-9.
Stem and Precursor Cells
Pretzel D, Linss S, Rochler S, Endres M, Kaps C, Alsalameh S, Kinne RW.
"Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage."
Arthritis Res Ther. 2011 Apr 15;13(2):R64.
Endres M, Andreas K, Kalwitz G, Freymann U, Neumann K, Ringe J, Sittinger M, Häupl T, Kaps C.
"Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells."
Osteoarthritis Cartilage. 2010 Nov; 18(11):1458-66.
Kalwitz G, Endres M, Neumann K, Skriner K, Ringe J, Sezer O, Sittinger M, Häupl T, Kaps C.
"Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7. "
Int J Biochem Cell Biol. 2009 Mar;41(3):649-58.
Neumann K, Dehne T, Endres M, Erggelet C, Kaps C, Ringe J, Sittinger M.
"Chondrogenic differentiation capacity of human mesenchymal progenitor cells derived from subchondral cortico-spongious bone."
J Orthop Res. 2008 Nov;26(11):1449-56.
Endres M, Neumann K, Häupl T, Erggelet C, Ringe J, Sittinger M, Kaps C.
"Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow."
J Orthop Res. 2007 Oct;25(10):1299-307.
Drug Screening
Andreas K, Häupl T, Lübke C, Ringe J, Morawietz L, Wachtel A, Sittinger M, Kaps C.
"Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. "
Arthritis Res Ther. 2009;11(1):R15. Epub 2009 Feb 3.
Andreas K, Lübke C, Häupl T, Dehne T, Morawietz L, Ringe J, Kaps C, Sittinger M.
"Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. "
Arthritis Res Ther. 2008;10(1):R9. Epub 2008 Jan 18.
Häupl T, Yahyawi M, Lübke C, Ringe J, Rohrlach T, Burmester GR, Sittinger M, Kaps C.
"Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. " J Biomol Screen. 2007 Apr;12(3):328-40.
Smolian H, Thiele S, Kolkenbrock H, Zacher J, Aicher W, Schultz O, Burmester GR, Sittinger M.
"Establishment of an in vitro model for rheumatoid arthritis as test system for therapeutical substances."
ALTEX – Alternativen zum Tierexperiment. 2001;18(4):265-80.
Kreuz PC, Müller S, Freymann U, Erggelet C, Niemeyer P, Kaps C, Hirschmüller A.
"Repair of focal cartilage defects with scaffold-assisted autologous chondrocyte grafts: clinical and biomechanical results 48 months after transplantation. "
Am J Sports Med. 2011 Aug;39(8):1697-705.
Patrascu JM, Freymann U, Kaps C, Poenaru DV.
"Repair of a post-traumatic cartilage defect with a cell-free polymer-based cartilage implant: A follow-up at two years by mri and histological review. "
J Bone Joint Surg Br. 2010:92:1160-1163.
Endres M, Abbushi A, Thomale UW, Cabraja M, Kroppenstedt SN, Morawietz L, Casalis PA, Zenclussen ML, Lemke AJ, Horn P, Kaps C, Woiciechowsky C.
"Intervertebral disc regeneration after implantation of a cell-free bioresorbable implant in a rabbit disc degeneration model."
Biomaterials. 2010 Aug;31(22):5836-41.
Zantop T, Petersen, W.
"Arthroscopic Implantation of a matrix to cover large chondral defect during microfracture: case report with video illustration. "
Arthroscopy. 2009 Nov;25:1354-1360.
Erggelet C, Endres M, Neumann K, Morawietz L, Ringe J, Haberstroh K, Sittinger M, Kaps C.
"Formation of Cartilage Repair Tissue in Articular Cartilage Defects Pretreated with Microfracture and Covered with Cell-Free Polymer-Based Implants."
J Orthop Res. 2009 Oct;27(10):1353-60.
Kreuz PC, Muller S, Ossendorf C, Kaps C, Erggelet C.
"Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four year clinical results."
Arthritis Res Ther. 2009 Mar 5;11(2):R33
Ossendorf C, Kaps C, Kreuz PC, Burmester GR, Sittinger M, Erggelet C.
"Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results." Arthritis Res Ther. 2007;9(2):R41.
Schmelzeisen R, Schimming R, Sittinger M.
"Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary report." Journal of Craniomaxillofacial Surgery. 2003 Feb;31(1):34-9.
Stem and Precursor Cells
Pretzel D, Linss S, Rochler S, Endres M, Kaps C, Alsalameh S, Kinne RW.
"Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage."
Arthritis Res Ther. 2011 Apr 15;13(2):R64.
Endres M, Andreas K, Kalwitz G, Freymann U, Neumann K, Ringe J, Sittinger M, Häupl T, Kaps C.
"Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells."
Osteoarthritis Cartilage. 2010 Nov; 18(11):1458-66.
Kalwitz G, Endres M, Neumann K, Skriner K, Ringe J, Sezer O, Sittinger M, Häupl T, Kaps C.
"Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7. "
Int J Biochem Cell Biol. 2009 Mar;41(3):649-58.
Neumann K, Dehne T, Endres M, Erggelet C, Kaps C, Ringe J, Sittinger M.
"Chondrogenic differentiation capacity of human mesenchymal progenitor cells derived from subchondral cortico-spongious bone."
J Orthop Res. 2008 Nov;26(11):1449-56.
Endres M, Neumann K, Häupl T, Erggelet C, Ringe J, Sittinger M, Kaps C.
"Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow."
J Orthop Res. 2007 Oct;25(10):1299-307.
Drug Screening
Andreas K, Häupl T, Lübke C, Ringe J, Morawietz L, Wachtel A, Sittinger M, Kaps C.
"Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. "
Arthritis Res Ther. 2009;11(1):R15. Epub 2009 Feb 3.
Andreas K, Lübke C, Häupl T, Dehne T, Morawietz L, Ringe J, Kaps C, Sittinger M.
"Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. "
Arthritis Res Ther. 2008;10(1):R9. Epub 2008 Jan 18.
Häupl T, Yahyawi M, Lübke C, Ringe J, Rohrlach T, Burmester GR, Sittinger M, Kaps C.
"Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. " J Biomol Screen. 2007 Apr;12(3):328-40.
Smolian H, Thiele S, Kolkenbrock H, Zacher J, Aicher W, Schultz O, Burmester GR, Sittinger M.
"Establishment of an in vitro model for rheumatoid arthritis as test system for therapeutical substances."
ALTEX – Alternativen zum Tierexperiment. 2001;18(4):265-80.